5-HT2CRs expressed by pro-opiomelanocortin neurons regulate insulin sensitivity in liver
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منابع مشابه
5-HT2CRs Expressed by Pro-Opiomelanocortin Neurons Regulate Energy Homeostasis
Drugs activating 5-hydroxytryptamine 2C receptors (5-HT2CRs) potently suppress appetite, but the underlying mechanisms for these effects are not fully understood. To tackle this issue, we generated mice with global 5-HT2CR deficiency (2C null) and mice with 5-HT2CRs re-expression only in pro-opiomelanocortin (POMC) neurons (2C/POMC mice). We show that 2C null mice predictably developed hyperpha...
متن کاملSerotonin 2C receptors in pro-opiomelanocortin neurons regulate energy and glucose homeostasis.
Energy and glucose homeostasis are regulated by central serotonin 2C receptors. These receptors are attractive pharmacological targets for the treatment of obesity; however, the identity of the serotonin 2C receptor-expressing neurons that mediate the effects of serotonin and serotonin 2C receptor agonists on energy and glucose homeostasis are unknown. Here, we show that mice lacking serotonin ...
متن کاملHeterogeneity of hypothalamic pro-opiomelanocortin-expressing neurons revealed by single-cell RNA sequencing
OBJECTIVE Arcuate proopiomelanocortin (POMC) neurons are critical nodes in the control of body weight. Often characterized simply as direct targets for leptin, recent data suggest a more complex architecture. METHODS Using single cell RNA sequencing, we have generated an atlas of gene expression in murine POMC neurons. RESULTS Of 163 neurons, 118 expressed high levels of Pomc with little/no...
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Zucker (fa/fa) rats with defective leptin receptors are obese, hyperphagic, and hyperinsulinemic. For testing whether chronic activation of the central melanocortin pathway can bypass the defective leptin signaling and normalize altered energy homeostasis in these rats, recombinant adeno-associated virus encoding pro-opiomelanocortin (rAAV-POMC) or control vector was delivered bilaterally into ...
متن کاملPro-opiomelanocortin Peptides in Mouse Pituitary Cells*
Pro-opiomelanocortin (POMC) is glycosylated and proteolytically cleaved to produce a number of smaller peptide hormones including adrenocorticotropic hormone (ACTH) and endorphin in mammalian pituitary and the mouse pituitary cell Line AtT-20/DI6,. When glycosylation of POMC is inhibited in AtT-20 cells with the drug tunicamycin, a 26,000-dalton protein appears in place of the glycosylated 29,0...
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ژورنال
عنوان ژورنال: Nature Neuroscience
سال: 2010
ISSN: 1097-6256,1546-1726
DOI: 10.1038/nn.2664